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Crisp4tm1.2Mkob
Targeted Allele Detail
Summary
Symbol: Crisp4tm1.2Mkob
Name: cysteine-rich secretory protein 4; targeted mutation 1.2, Moira K O'Bryan
MGI ID: MGI:4950060
Gene: Crisp4  Location: Chr1:18185415-18216126 bp, - strand  Genetic Position: Chr1, 5.65 cM, cytoband A4
Alliance: Crisp4tm1.2Mkob page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171346
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into intron 2 and a floxed neo cassette was inserted into intro 3 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 3. Western blot and immunohistochemical analysis confirmed the absence of protein expression in epididymides from homozygous mice. (J:171346)
Generation of the Crisp4tm1.1Mkob and Crisp4tm1.2Mkob alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crisp4 Mutation:  21 strains or lines available
References
Original:  J:171346 Gibbs GM, et al., Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7034-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory