Igh-8tm1.1Aak
Targeted Allele Detail
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Symbol: |
Igh-8tm1.1Aak |
Name: |
immunoglobulin heavy chain 8 (heavy chain of IgG3); targeted mutation 1.1, Ahmed Khamlichi |
MGI ID: |
MGI:4950362 |
Synonyms: |
pApgamma |
Gene: |
Igh-8 Location: Chr12:113329416-113330847 bp Genetic Position: Chr12, Syntenic
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Alliance: |
Igh-8tm1.1Aak page
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Germline Transmission: |
Earliest citation of germline transmission:
J:171251
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Parent Cell Line: |
CK35 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Not Applicable) |
Mutation: |
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Insertion
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Mutation details: A transcriptional terminator cassette containing two polyadenylation signals in the sense orientation and three in the antisense orientation was inserted together with a floxed neomycin selection cassette 251 bp downstream of the Ig3 exon. The selection cassette was subsequently removed by cre mediated excison.
(J:171251)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Igh-8 Mutation: |
5 strains or lines available
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Original: |
J:171251 Haddad D, et al., Sense transcription through the S region is essential for immunoglobulin class switch recombination. EMBO J. 2011 Apr 20;30(8):1608-20 |
All: |
1 reference(s) |
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