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Igh-8tm1.1Aak
Targeted Allele Detail
Summary
Symbol: Igh-8tm1.1Aak
Name: immunoglobulin heavy chain 8 (heavy chain of IgG3); targeted mutation 1.1, Ahmed Khamlichi
MGI ID: MGI:4950362
Synonyms: pApgamma
Gene: Igh-8  Location: Chr12:113329416-113330847 bp  Genetic Position: Chr12, Syntenic
Alliance: Igh-8tm1.1Aak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171251
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Insertion
 
Mutation detailsA transcriptional terminator cassette containing two polyadenylation signals in the sense orientation and three in the antisense orientation was inserted together with a floxed neomycin selection cassette 251 bp downstream of the Ig3 exon. The selection cassette was subsequently removed by cre mediated excison. (J:171251)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh-8 Mutation:  5 strains or lines available
References
Original:  J:171251 Haddad D, et al., Sense transcription through the S region is essential for immunoglobulin class switch recombination. EMBO J. 2011 Apr 20;30(8):1608-20
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory