Rhoa^tm1Jrel
Targeted Allele Detail

Summary

• Symbol: Rhoa^tm1Jrel
• Name: ras homolog family member A; targeted mutation 1, Joao B Relvas
• MGI ID: MGI:4950374
• Synonyms: Rho^lox
• Gene: Rhoa Location: Chr9:108183359-108215142 bp, + strand Genetic Position: Chr9, 59.2 cM
• Alliance: Rhoa^tm1Jrel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171199
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette. (J:171199, J:182206)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhoa Mutation: 73 strains or lines available

References

• Original: J:171199 Herzog D, et al., The Small GTPase RhoA Is Required to Maintain Spinal Cord Neuroepithelium Organization and the Neural Stem Cell Pool. J Neurosci. 2011 Mar 30;31(13):5120-5130
• All: 25 reference(s)