Cryba2^Aca30
Chemically induced Allele Detail

Summary

• Symbol: Cryba2^Aca30
• Name: crystallin, beta A2; ACMaster abnormality 30
• MGI ID: MGI:4950379
• Synonyms: Aca30, Cryba2^A
• Gene: Cryba2 Location: Chr1:74929093-74932302 bp, - strand Genetic Position: Chr1, 38.54 cM
• Alliance: Cryba2^Aca30 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C transition in exon 2 that results in the amino acid substitution of proline for serine at position 47 (S47P). (J:171541)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cryba2 Mutation: 17 strains or lines available

References

• Original: J:171541 Puk O, et al., First Mutation in the {beta}A2-crystallin Encoding Gene is Associated with Small Lenses and Age-Related Cataracts. Invest Ophthalmol Vis Sci. 2011 Apr;52(5):2571-6
• All: 2 reference(s)