Myoc^{tm3(cre/ERT2)Rjo}
Targeted Allele Detail

Summary

• Symbol: Myoc^{tm3(cre/ERT2)Rjo}
• Name: myocilin; targeted mutation 3, Randy L Johnson
• MGI ID: MGI:4950391
• Synonyms: Myoc-CreER(T2)
• Gene: Myoc Location: Chr1:162466724-162477262 bp, + strand Genetic Position: Chr1, 70.29 cM
• Alliance: Myoc^{tm3(cre/ERT2)Rjo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171549
• Parent Cell Line: RJ2.2 (ES Cell)
• Strain of Origin: (C57BL/6Brd-Tyr^c-Brd x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Myoc^{tm3(cre/ERT2)Rjo} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myoc (MGI:1202864)

• Mutation details: A targeting vector was constructed so that homology arms flanked a cassette containing an IRES-cre/ERT2-pA-neo-loxP-pA sequence. Homologous recombination in RJ2.2 ES cells resulted in insertion of the cassette into the 3' UTR of the Myoc locus. (J:171549)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myoc (mouse) Summary of all recombinase alleles driven by Myoc. Alliance mouse Myoc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myoc Mutation: 27 strains or lines available

References

• Original: J:171549 Liu P, et al., Efficient in vivo doxycycline and cre recombinase-mediated inducible transgene activation in the murine trabecular meshwork. Invest Ophthalmol Vis Sci. 2011 Feb;52(2):969-74
• All: 1 reference(s)