Flrt2^tm1Rob
Targeted Allele Detail

Summary

• Symbol: Flrt2^tm1Rob
• Name: fibronectin leucine rich transmembrane protein 2; targeted mutation 1, Elizabeth J Robertson
• MGI ID: MGI:4950410
• Gene: Flrt2 Location: Chr12:95659000-95751989 bp, + strand Genetic Position: Chr12, 46.44 cM
• Alliance: Flrt2^tm1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171515
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed hygro cassette replaced exon 2. The absence of protein expression was confirmed by western blot analysis on E11.5 embryo extracts. (J:171515)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Flrt2 Mutation: 45 strains or lines available

References

• Original: J:171515 Muller PS, et al., The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis. Development. 2011 Apr;138(7):1297-308
• All: 2 reference(s)