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Xisttm5.2Nbd
Targeted Allele Detail
Summary
Symbol: Xisttm5.2Nbd
Name: inactive X specific transcripts; targeted mutation 5.2, Neil Brockdorff
MGI ID: MGI:4950441
Synonyms: XistINV
Gene: Xist  Location: ChrX:102503979-102526839 bp, - strand  Genetic Position: ChrX, 46.15 cM, cytoband D
Alliance: Xisttm5.2Nbd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171502
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Intragenic deletion, Inversion
  Xisttm5.2Nbd involves 1 genes/genome features (Xist) View all
 
Mutation detailsA floxed neo cassette was inserted into exon 1 in ES cells containing Xisttm4.1Nbd, which lacks exon 4. Cre-mediated recombination removed the neo cassette and inverts the sequence between the loxP site (including exon 3, exon 2, and the 3' portion of exon 1). (J:171502)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xist Mutation:  8 strains or lines available
References
Original:  J:171502 Senner CE, et al., Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation. Development. 2011 Apr;138(8):1541-50
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory