Ins2^{tm1(cre/ERT2)Kcmm}
Targeted Allele Detail

Summary

• Symbol: Ins2^{tm1(cre/ERT2)Kcmm}
• Name: insulin II; targeted mutation 1, Susumu Seino
• MGI ID: MGI:4950476
• Synonyms: Ins2-CreERT2
• Gene: Ins2 Location: Chr7:142232393-142233463 bp, - strand Genetic Position: Chr7, 88.0 cM
• Alliance: Ins2^{tm1(cre/ERT2)Kcmm} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171567
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Ins2^{tm1(cre/ERT2)Kcmm} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ins2 (MGI:96573)

• Mutation details: A cre/ERT2 cassette was inserted into the ATG site in exon2 of the mouse Ins2 gene by homologous recombination, replacing exons 2 and 3. Expression of cre recombinase was only detected in insulin-expressing beta cells. (J:171567)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ins2 (mouse) Summary of all recombinase alleles driven by Ins2. Alliance mouse Ins2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ins2 Mutation: 93 strains or lines available

References

• Original: J:171567 Nakamura K, et al., Pancreatic beta-cells are generated by neogenesis from non-beta-cells after birth. Biomed Res. 2011;32(2):167-74
• All: 3 reference(s)