Abi1^tm1.1Lko
Targeted Allele Detail

Summary

• Symbol: Abi1^tm1.1Lko
• Name: abl interactor 1; targeted mutation 1.1, Leszek Kotula
• MGI ID: MGI:4950557
• Gene: Abi1 Location: Chr2:22830085-22930207 bp, - strand Genetic Position: Chr2, 15.18 cM
• Alliance: Abi1^tm1.1Lko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171342
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A single loxP site was inserted 5' of exon 1 and a floxed and FRT flanked neo cassette was inserted 3' of exon 1 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:171342)

Generation of the Abi1^tm1.1Lko and Abi1^tm1.2Lko alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abi1 Mutation: 78 strains or lines available

References

• Original: J:171342 Dubielecka PM, et al., Essential role for Abi1 in embryonic survival and WAVE2 complex integrity. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7022-7
• All: 2 reference(s)