Grin1^tm2.1Stl
Targeted Allele Detail

Summary

• Symbol: Grin1^tm2.1Stl
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 2.1, Susumu Tonegawa
• MGI ID: MGI:4950588
• Synonyms: Grin1^Delta, Grin1^null
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm2.1Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170830
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Grin1^tm2Stl homozygous mice were bred to the deleter strain Meox2^{tm1(cre)Sor/+} to generate mice with global deletion of one copy of Grin1. (J:37457, J:170830)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 67 strains or lines available

References

• Original: J:170830 Beutler LR, et al., Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4206-11
• All: 7 reference(s)