Tg(PDGFB-LRRK2*G2019S)340Djmo
Transgene Detail

Summary

• Symbol: Tg(PDGFB-LRRK2*G2019S)340Djmo
• Name: transgene insertion 340, Darren Moore
• MGI ID: MGI:4950671
• Synonyms: G2019S-LRRK2
• Transgene: Tg(PDGFB-LRRK2*G2019S)340Djmo Location: unknown
• Alliance: Tg(PDGFB-LRRK2*G2019S)340Djmo page

Progressive loss of substantia nigra dopaminergic neurons in Tg(PDGFB-LRRK2*G2019S)340Djmo/0 transgenic mice

Show the 6 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-LRRK2*G2019S)340Djmo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: The G2019S-LRRK2 transgene was designed with a minimal cytomegalovirus (CMV) enhancer and human platelet derived growth factor, B polypeptide (PDGFB) promoter/enhancer elements driving expression of a full length human leucine-rich repeat kinase 2 (LRRK2) cDNA. LRRK2 cDNA was modified by targeted mutation of the LRRK2 locus to harbor the LRRK2*G2019S mutation associated with autosomal dominant, late-onset Parkinson's disease. Line 340 was generated. (J:171645)

Schematic of the Tg(PDGFB-LRRK2*G2019S)340Djmo or Tg(PDGFB-LRRK2*R1441C)574Djmo transgene

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:171645 Ramonet D, et al., Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2. PLoS One. 2011;6(4):e18568
• All: 7 reference(s)