Foxp3^{tm1(CD2/CD52)Shori}
Targeted Allele Detail

Summary

• Symbol: Foxp3^{tm1(CD2/CD52)Shori}
• Name: forkhead box P3; targeted mutation 1, Shohei Hori
• MGI ID: MGI:4950682
• Synonyms: Foxp3-hCD2, Foxp3^hCD2, Foxp3^hCD2/hCD52, Foxp3-IRES-hCD2/hCD52
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^{tm1(CD2/CD52)Shori} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171646
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: Sequence encoding a GPI-anchored reporter fusion of human CD2 and CD52 preceded by an IRES was inserted into the 3' UTR. Cre-mediated recombination removed a floxed neomycin resistance cassette downstream of the fusion. (J:171646, J:215863)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Foxp3^tm1(CD2/CD52)Shori/Foxp3^tm1(CD2/CD52)Shori	involves: C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
hematopoietic system	√
decreased regulatory T cell number	√
immune system	√
decreased regulatory T cell number	√
increased susceptibility to type IV hypersensitivity reaction	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 58 strains or lines available

References

• Original: J:171646 Komatsu N, et al., Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1903-8
• All: 52 reference(s)