Dync1li1m1Emcf
Chemically induced Allele Detail
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Symbol: |
Dync1li1m1Emcf |
Name: |
dynein cytoplasmic 1 light intermediate chain 1; mutation 1, Elizabeth M C Fisher |
MGI ID: |
MGI:4950685 |
Synonyms: |
Dync1li1N235Y |
Gene: |
Dync1li1 Location: Chr9:114517899-114552856 bp, + strand Genetic Position: Chr9, 64.96 cM
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Alliance: |
Dync1li1m1Emcf page
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Allele Type: |
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Chemically induced (ENU) |
Mutation: |
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Single point mutation
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Mutation details: ENU mutagenesis induced a A to T transversion within exon 5 that results in the amino acid substitution of tyrosine for asparagine at position 235 (N235Y).
(J:63816, J:171267)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: BALB/cAnNCrl * C3H/HeH * C57BL/6 | |
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Phenotypes: |
Affected Systems |
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behavior/neurological
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behavior/neurological phenotype
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N
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decreased exploration in new environment
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√
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increased anxiety-related response
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√
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increased grip strength
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√
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abnormal gait
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√
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cellular
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√
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abnormal neuronal migration
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√
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abnormal lysosome physiology
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√
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digestive/alimentary system
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√
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increased defecation amount
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√
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nervous system
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√
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nervous system phenotype
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N
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abnormal neuronal migration
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√
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abnormal dendrite morphology
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√
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abnormal action potential
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:171267 Banks GT, et al., Behavioral and Other Phenotypes in a Cytoplasmic Dynein Light Intermediate Chain 1 Mutant Mouse. J Neurosci. 2011 Apr 6;31(14):5483-5494 |
All: |
2 reference(s) |
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