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Dync1li1m1Emcf
Chemically induced Allele Detail
Summary
Symbol: Dync1li1m1Emcf
Name: dynein cytoplasmic 1 light intermediate chain 1; mutation 1, Elizabeth M C Fisher
MGI ID: MGI:4950685
Synonyms: Dync1li1N235Y
Gene: Dync1li1  Location: Chr9:114517899-114552856 bp, + strand  Genetic Position: Chr9, 64.96 cM
Alliance: Dync1li1m1Emcf page
Mutation
origin
Strain of Origin:  BALB/cAnNCrl
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced a A to T transversion within exon 5 that results in the amino acid substitution of tyrosine for asparagine at position 235 (N235Y). (J:63816, J:171267)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: BALB/cAnNCrl * C3H/HeH * C57BL/6
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
behavior/neurological
behavior/neurological phenotype
N
decreased exploration in new environment
increased anxiety-related response
increased grip strength
abnormal gait
cellular
abnormal neuronal migration
abnormal lysosome physiology
digestive/alimentary system
increased defecation amount
nervous system
nervous system phenotype
N
abnormal neuronal migration
abnormal dendrite morphology
abnormal action potential
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dync1li1 Mutation:  57 strains or lines available
References
Original:  J:171267 Banks GT, et al., Behavioral and Other Phenotypes in a Cytoplasmic Dynein Light Intermediate Chain 1 Mutant Mouse. J Neurosci. 2011 Apr 6;31(14):5483-5494
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory