Hdac2^tm1.1Eem
Targeted Allele Detail

Summary

• Symbol: Hdac2^tm1.1Eem
• Name: histone deacetylase 2; targeted mutation 1.1, Edward E Morrisey
• MGI ID: MGI:4950697
• Synonyms: HDAC2^loxP
• Gene: Hdac2 Location: Chr10:36850540-36877885 bp, + strand Genetic Position: Chr10, 19.44 cM, cytoband B1
• Alliance: Hdac2^tm1.1Eem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171358
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette. (J:171358)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac2 Mutation: 40 strains or lines available

References

• Original: J:171358 Anokye-Danso F, et al., Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency. Cell Stem Cell. 2011 Apr 8;8(4):376-88
• All: 3 reference(s)