Zfp830^tm2.1Cota
Targeted Allele Detail

Summary

• Symbol: Zfp830^tm2.1Cota
• Name: zinc finger protein 830; targeted mutation 2.1, Michel Cohen-Tannoudji
• MGI ID: MGI:4950702
• Synonyms: Omcg1^flox
• Gene: Zfp830 Location: Chr11:82655171-82656761 bp, + strand Genetic Position: Chr11, 50.22 cM
• Alliance: Zfp830^tm2.1Cota page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171647
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Single point mutation
• Mutation details: A loxP site was inserted upstream of the single coding exon. A floxed neo cassette was inserted downstream of the coding exon. Flp-mediated recombination removed the neo cassette. This allele also contains a G to T transition at nucleotide 299 (GenBank accession HM446523) that results in the non-synonymous variation of valine for glycine at position 92 (G92V). (J:171647)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp830 Mutation: 14 strains or lines available

References

• Original: J:171647 Houlard M, et al., DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency. Cell Cycle. 2011 Jan 1;10(1):108-17
• All: 3 reference(s)