Ppargc1a^tm1.1Amos
Targeted Allele Detail

Summary

• Symbol: Ppargc1a^tm1.1Amos
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; targeted mutation 1.1, Antonio Moschetta
• MGI ID: MGI:4950745
• Synonyms: PGC1a^-, PGC1alpha^-
• Gene: Ppargc1a Location: Chr5:51611592-51725068 bp, - strand Genetic Position: Chr5, 27.02 cM, cytoband C1
• Alliance: Ppargc1a^tm1.1Amos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171361
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6JOlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin selection cassette replaced sequence spanning from intron 2 through intron5 (deleting exons 3-5). The selection cassette was subsequently excised by breeding to a cre-deleter mouse strain. (J:171361)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppargc1a Mutation: 48 strains or lines available

Notes

ES cell line = AZX1 (C57BL/6JOlaHsd).

References

• Original: J:171361 D'Errico I, et al., Peroxisome proliferator-activated receptor-{gamma} coactivator 1-{alpha} (PGC1{alpha}) is a metabolic regulator of intestinal epithelial cell fate. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6603-8
• All: 2 reference(s)