Ppp2ca^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Ppp2ca^tm1.1Nju
• Name: protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; targeted mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:4950915
• Synonyms: PP2Acalpha^flox, Ppp2ca^fl
• Gene: Ppp2ca Location: Chr11:51989651-52013576 bp, + strand Genetic Position: Chr11, 31.86 cM
• Alliance: Ppp2ca^tm1.1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171578
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked selection cassette and loxP site were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 5 via homologous recombination. Flp mediated recombination removed the selection cassette. (J:171578, J:184036)

Expression

In Mice Carrying this Mutation:	62 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp2ca Mutation: 25 strains or lines available

References

• Original: J:171578 Chen W, et al., Protein Phosphatase 2A Catalytic Subunit alpha (PP2Acalpha) Maintains Survival of Committed Erythroid Cells in Fetal Liver Erythropoiesis through the STAT5 Pathway. Am J Pathol. 2011 May;178(5):2333-43
• All: 9 reference(s)