Ehd3^tm1.2Haba
Targeted Allele Detail

Summary

• Symbol: Ehd3^tm1.2Haba
• Name: EH-domain containing 3; targeted mutation 1.2, Hamid Band
• MGI ID: MGI:4950928
• Gene: Ehd3 Location: Chr17:74111836-74139088 bp, + strand Genetic Position: Chr17, 45.2 cM, cytoband E2
• Alliance: Ehd3^tm1.2Haba page

Smaller size and pale, small kidneys in Ehd3^tm1.2Haba/Ehd3^tm1.2Haba Ehd4^tm1.1Haba/Ehd4^tm1.1Haba mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171715
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exon 1. The absence of protein expression was confirmed by western blot analysis in lung, kidney, heart, spleen, brain, and liver extracts. (J:171715)

Generation of the Ehd3^tm1.1Haba and Ehd3^tm1.2Haba alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ehd3 Mutation: 26 strains or lines available

References

• Original: J:171715 George M, et al., Renal thrombotic microangiopathy in mice with combined deletion of endocytic recycling regulators EHD3 and EHD4. PLoS One. 2011;6(3):e17838
• All: 3 reference(s)