Foxp3^{tm9(EGFP/cre/ERT2)Ayr}
Targeted Allele Detail

Summary

• Symbol: Foxp3^{tm9(EGFP/cre/ERT2)Ayr}
• Name: forkhead box P3; targeted mutation 9, Alexander Y Rudensky
• MGI ID: MGI:4950935
• Synonyms: Foxp3^{eGFP-Cre-ERT2}, Foxp3-GFP-Cre
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^{tm9(EGFP/cre/ERT2)Ayr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171734
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Foxp3^{tm9(EGFP/cre/ERT2)Ayr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxp3 (MGI:1891436)

• Mutation details: An IRES element followed by an EGFP-cre-ERT2 coding sequence was knocked into the 3' UTR of the Foxp3 locus. (J:171734)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxp3 (mouse) Summary of all recombinase alleles driven by Foxp3. Alliance mouse Foxp3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 58 strains or lines available

References

• Original: J:171734 Rubtsov YP, et al., Stability of the regulatory T cell lineage in vivo. Science. 2010 Sep 24;329(5999):1667-71
• All: 84 reference(s)