Prxl2a^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Prxl2a^{tm1(KOMP)Vlcg}
• Name: peroxiredoxin like 2A; targeted mutation 1, Velocigene
• MGI ID: MGI:4951256
• Synonyms: Adrx KO
• Gene: Prxl2a Location: Chr14:40715697-40735745 bp, - strand Genetic Position: Chr14, 22.36 cM
• Alliance: Prxl2a^{tm1(KOMP)Vlcg} page
• IMPC: Prxl2a gene page

Mutation origin

• Mutant Cell Lines: 15730A-A10, 15730A-C9, 15730A-G11, 15730A-H5, 15730A-H8
• Germline Transmission: Earliest citation of germline transmission: J:234040
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 9694bp between positions 40716446-40726139 of Chromosome 14 (Build GRCm39). Exons 2-6 are deleted. Immunoblot analysis confirmed the absence of protein expression in whole adipose tissue lysates from homozygous mutant mice. (J:136110, J:234040)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Prxl2a Mutation: 14 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 2 reference(s)