Adamts14^{Gt(511E11)Cmhd}
Gene trapped Allele Detail

Summary

• Symbol: Adamts14^{Gt(511E11)Cmhd}
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 14; gene trap 511E11, Centre for Modeling Human Disease
• MGI ID: MGI:4954752
• Synonyms: TS14^-
• Gene: Adamts14 Location: Chr10:61032891-61109217 bp, - strand Genetic Position: Chr10, 32.16 cM
• Alliance: Adamts14^{Gt(511E11)Cmhd} page

Mutation origin

• Mutant Cell Line: 511E11
• Germline Transmission: Earliest citation of germline transmission: J:271185
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: UPA
• A gene trap vector inserted between bases 9251 and 9252 of intron 4. (J:271185)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  CMHD-GT_511E11-5S	FI279020 ; (MGI Seq Detail)	5'Splinkerette PCR	Chr10:61072488-61073116 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  29 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Adamts14^Gt(511E11)Cmhd/Adamts14^Gt(511E11)Cmhd	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6
hm2	Adamts14^Gt(511E11)Cmhd/Adamts14^Gt(511E11)Cmhd	involves: 129S1/Sv * 129X1/SvJ
cx3	Adamts14^Gt(511E11)Cmhd/Adamts14^Gt(511E11)Cmhd Adamts2^tm1Prc/Adamts2^tm1Prc	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

Phenotypes:

Affected Systems	hm1	hm2	cx3
show or hide all annotated terms
cellular			√
increased keratinocyte apoptosis			√
increased T cell proliferation			√
increased keratinocyte proliferation			√
hematopoietic system			√
cutaneous mastocytosis			√
decreased B cell number			√
increased CD4-positive, alpha-beta T cell number			√
decreased CD8-positive, alpha-beta T cell number			√
abnormal T cell activation			√
increased T cell proliferation			√
homeostasis/metabolism	N		√
homeostasis/metabolism phenotype	N		N
abnormal homeostasis			√
immune system	√		√
cutaneous mastocytosis			√
decreased B cell number			√
increased CD4-positive, alpha-beta T cell number			√
decreased CD8-positive, alpha-beta T cell number			√
abnormal T cell activation			√
increased T cell proliferation			√
increased interferon-gamma secretion	√		√
increased interleukin-2 secretion	√		√
dermatitis			√
integument	N		√
integument phenotype	N		N
increased keratinocyte apoptosis			√
increased keratinocyte proliferation			√
dermatitis			√
ruffled hair			√
abnormal cutaneous collagen fibril morphology			√
dermal hyperplasia			√
mixed cellular infiltration to dermis			√
thick epidermis			√
spontaneous skin ulceration			√
decreased skin tensile strength			√
muscle	N		√
muscle phenotype	N
abnormal tendon collagen fibril morphology			√
reproductive system			√
male infertility			√
skeleton			√
abnormal tendon collagen fibril morphology			√
vision/eye	N		N
vision/eye phenotype	N		N
normal phenotype		√
no abnormal phenotype detected		√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts14 Mutation: 100 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 5 reference(s)