Kdm4b^tm1.2Okad
Targeted Allele Detail

Summary

• Symbol: Kdm4b^tm1.2Okad
• Name: lysine (K)-specific demethylase 4B; targeted mutation 1.2, Hitoshi Okada
• MGI ID: MGI:4999585
• Synonyms: Jmjd2b^delta
• Gene: Kdm4b Location: Chr17:56633062-56709870 bp, + strand Genetic Position: Chr17, 29.27 cM
• Alliance: Kdm4b^tm1.2Okad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171678
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed exon 5, which results in a frameshift and translation termination, and removal of H189 and E191 residues essential for demethylase activity. (J:171678)

Generation of the Kdm4b^tm1.1Okad and Kdm4b^tm1.2Okad alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm4b Mutation: 54 strains or lines available

References

• Original: J:171678 Kawazu M, et al., Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS One. 2011;6(3):e17830
• All: 1 reference(s)