Kdm4b^tm1.1Okad
Targeted Allele Detail

Summary

• Symbol: Kdm4b^tm1.1Okad
• Name: lysine (K)-specific demethylase 4B; targeted mutation 1.1, Hitoshi Okada
• MGI ID: MGI:4999586
• Synonyms: Jmjd2b^flox
• Gene: Kdm4b Location: Chr17:56633062-56709870 bp, + strand Genetic Position: Chr17, 29.27 cM
• Alliance: Kdm4b^tm1.1Okad page

Defective mammary gland development in Kdm4b^tm1.1Okad/Kdm4b^tm1.1Okad Tg(MMTV-cre)1Mam/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171678
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette. (J:171678)

Generation of the Kdm4b^tm1.1Okad and Kdm4b^tm1.2Okad alleles

Expression

In Mice Carrying this Mutation:

11 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm4b Mutation: 54 strains or lines available

References

• Original: J:171678 Kawazu M, et al., Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS One. 2011;6(3):e17830
• All: 3 reference(s)