Ptpn6^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptpn6^m2Btlr
• Name: protein tyrosine phosphatase, non-receptor type 6; mutation 2, Bruce Beutler
• MGI ID: MGI:4999612
• Synonyms: spin2
• Gene: Ptpn6 Location: Chr6:124697670-124715672 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Ptpn6^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C transition at nucleotide 449 (Genbank record NM_013545) in exon 4 of 17 total exons that results in the amino acid substitution of leucine to proline at amino acid 86 (L86P). (J:171740)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn6 Mutation: 49 strains or lines available

References

• Original: J:171740 Beutler B, Direct Data Submission 2011/05/23. MGI Direct Data Submission. 2011
• All: 1 reference(s)