Creb1^tm3.1Gsc
Targeted Allele Detail

Summary

• Symbol: Creb1^tm3.1Gsc
• Name: cAMP responsive element binding protein 1; targeted mutation 3.1, Gunther Schutz
• MGI ID: MGI:4999627
• Synonyms: Creb1^-
• Gene: Creb1 Location: Chr1:64571963-64643707 bp, + strand Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
• Alliance: Creb1^tm3.1Gsc page

Lung development abnormalities in Creb1^tm3.1Gsc/Creb1^tm3.1Gsc mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171712
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site was inserted 5' to exon 10 and a loxP flanked neomycin and thymidine kinase cassette was inserted 3' to exon 10. Cre mediated recombination removed the selection cassette and exon 10. (J:76211, J:171712)

Expression

In Mice Carrying this Mutation:	37 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Creb1 Mutation: 61 strains or lines available

References

• Original: J:171712 Bird AD, et al., cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development. PLoS One. 2011;6(3):e17843
• All: 3 reference(s)