Slc39a14^tm1Thir
Targeted Allele Detail

Summary

• Symbol: Slc39a14^tm1Thir
• Name: solute carrier family 39 (zinc transporter), member 14; targeted mutation 1, Toshio Hirano
• MGI ID: MGI:4999729
• Gene: Slc39a14 Location: Chr14:70540918-70588874 bp, - strand Genetic Position: Chr14, 36.32 cM
• Alliance: Slc39a14^tm1Thir page

Dwarfism, torticollis, scoliosis, osteopenia, and shortened long bones in Slc39a14^tm1Thir/Slc39a14^tm1Thir mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171670
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced exons 5 through 8. The absence of protein expression (isoform A and B) was confirmed by western blot analysis on liver extracts. (J:171670)

Generation of the Slc39a14^tm1Thir allele

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc39a14 Mutation: 69 strains or lines available

References

• Original: J:171670 Hojyo S, et al., The zinc transporter SLC39A14/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth. PLoS One. 2011;6(3):e18059
• All: 10 reference(s)