Guca1a^tm1.1Hunt
Targeted Allele Detail

Summary

• Symbol: Guca1a^tm1.1Hunt
• Name: guanylate cyclase activator 1a (retina); targeted mutation 1.1, David M Hunt
• MGI ID: MGI:4999776
• Synonyms: Guca1a^COD3
• Gene: Guca1a Location: Chr17:47705483-47711509 bp, - strand Genetic Position: Chr17, 23.07 cM, cytoband D
• Alliance: Guca1a^tm1.1Hunt page

Progressive loss of cone photoreceptors in Guca1a^tm1.1Hunt/Guca1a⁺ and Guca1a^tm1.1Hunt/Guca1a^tm1.1Hunt mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171667
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Humanized sequence) Mutation: Insertion Mutation details: Exon 4 was replaced with a floxed neo cassette and a modified exon 4, which contained an A to G transition that results in the amino acid substitution of glycine for glutamic acid at position 155 (E155G), mimicking a mutation found in some cone dystrophy 3 (COD3) patients. Cre-mediated recombination removed the neo cassette. (J:171667)

Generation of the Guca1a^tm1.1Hunt allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Guca1a Mutation: 12 strains or lines available

References

• Original: J:171667 Buch PK, et al., Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/Guca1a gene. PLoS One. 2011;6(3):e18089
• All: 2 reference(s)