Tg(IVL-cre/ERT2)1Blpn
Transgene Detail

Summary

• Symbol: Tg(IVL-cre/ERT2)1Blpn
• Name: transgene insertion 1, Cedric Blanpain
• MGI ID: MGI:4999984
• Synonyms: InvCREER, INV-CreERT2
• Transgene: Tg(IVL-cre/ERT2)1Blpn Location: unknown
• Alliance: Tg(IVL-cre/ERT2)1Blpn page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(IVL-cre/ERT2)1Blpn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  IVL (3713)

  Ivl	(MGI:96626)

• Mutation details: A cre/ERT2 fragment was cloned into a vector containing the human involucrin (IVL) promoter, the SV40 intron, and the SV40 polyA signal. The transgenic construct was microinjected into fertilized oocytes, and three founders were generated. Expression profiles were screened with crosses to ROSA-YFP reporter mice. (J:172048)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	IVL (human) Summary of all recombinase alleles driven by IVL. Alliance human IVL gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:172048 Lapouge G, et al., Identifying the cellular origin of squamous skin tumors. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7431-6
• All: 4 reference(s)