Hcrtr1^tm1Mmsc
Targeted Allele Detail

Summary

• Symbol: Hcrtr1^tm1Mmsc
• Name: hypocretin (orexin) receptor 1; targeted mutation 1, Michael M Scott
• MGI ID: MGI:5000034
• Gene: Hcrtr1 Location: Chr4:130024010-130033152 bp, - strand Genetic Position: Chr4, 63.43 cM
• Alliance: Hcrtr1^tm1Mmsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171751
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed transcription disrupter cassette was inserted into intron 3 via homologous recombination. In situ hybridization analysis confirmed the absence of expression in the central nervous system of homozygous mice. (J:171751)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hcrtr1 Mutation: 32 strains or lines available

References

• Original: J:171751 Scott MM, et al., Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. Behav Brain Res. 2011 Sep 23;222(2):289-94
• All: 1 reference(s)