Tg(AR*100Q)C25Als
Transgene Detail

Summary

• Symbol: Tg(AR*100Q)C25Als
• Name: transgene insertion C25, Albert La Spada
• MGI ID: MGI:5000265
• Synonyms: AR100, AR YAC CAG100
• Transgene: Tg(AR*100Q)C25Als Location: unknown
• Alliance: Tg(AR*100Q)C25Als page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:89772
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(AR*100Q)C25Als expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AR (367)

  Ar	(MGI:88064)

• Mutation details: The transgene contains a human YAC in which the CAG repeat contains 100 repeats (100Q). Lines C25 (high expressor) and C32 (low expressor) were generated. (J:89772)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:89772 Sopher BL, et al., Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration. Neuron. 2004 Mar 4;41(5):687-99
• All: 1 reference(s)