Tg(Gfap-gp120)#Lms
Transgene Detail

Summary

• Symbol: Tg(Gfap-gp120)#Lms
• Name: transgene insertion, Lennart Mucke
• MGI ID: MGI:5000435
• Transgene: Tg(Gfap-gp120)#Lms Location: unknown
• Alliance: Tg(Gfap-gp120)#Lms page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The env gene from the LAV strtain of HIV-1 was truncated to encode gp120 amino acids 1-509 and inserted in exon 1 of a modified murine Gfap gene. Five lines (2, 3,10, 16, 37) were established which varied in level of expression. Level of expression did not correlate with transgene copy number. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:146427)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Human Immunodeficiency Virus Infectious Disease J:170738, J:239462 (DOID:526).

References

• Original: J:170738 Lee MH, et al., Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease. Neurobiol Dis. 2011 Mar;41(3):678-87
• All: 14 reference(s)