Stab1^tm1.1Cger
Targeted Allele Detail

Summary

• Symbol: Stab1^tm1.1Cger
• Name: stabilin 1; targeted mutation 1.1 Cyrill Geraud
• MGI ID: MGI:5000470
• Gene: Stab1 Location: Chr14:30860970-30890598 bp, - strand Genetic Position: Chr14, 19.09 cM
• Alliance: Stab1^tm1.1Cger page

Liver fibrosis in Stab1^tm1.1Cger/Stab1^tm1.1Cger Stab2^tm1.1Cger/Stab2^tm1.1Cger mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171818
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 1. A neo cassette with a 3' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the neo cassette. Immunohistochemistry confirmed the absence of protein expression in the liver. (J:171818)

Generation of the Stab1^tm1.1Cger allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stab1 Mutation: 124 strains or lines available

References

• Original: J:171818 Schledzewski K, et al., Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest. 2011 Feb 1;121(2):703-14
• All: 6 reference(s)