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Stab2tm1.1Cger
Targeted Allele Detail
Summary
Symbol: Stab2tm1.1Cger
Name: stabilin 2; targeted mutation 1.1, Cyrill Geraud
MGI ID: MGI:5000471
Gene: Stab2  Location: Chr10:86677062-86843889 bp, - strand  Genetic Position: Chr10, 43.14 cM
Alliance: Stab2tm1.1Cger page
Liver fibrosis in Stab1tm1.1Cger/Stab1tm1.1Cger Stab2tm1.1Cger/Stab2tm1.1Cger mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171818
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette with a 5' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Cre-mediated recombination removed the neo cassette and exon 1. Immunohistochemistry confirmed the absence of protein expression in the liver. (J:171818)
Generation of the Stab2tm1.1Cger allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stab2 Mutation:  138 strains or lines available
References
Original:  J:171818 Schledzewski K, et al., Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest. 2011 Feb 1;121(2):703-14
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory