About   Help   FAQ
Stab2tm1.1Cger
Targeted Allele Detail
Summary
Symbol: Stab2tm1.1Cger
Name: stabilin 2; targeted mutation 1.1, Cyrill Geraud
MGI ID: MGI:5000471
Gene: Stab2  Location: Chr10:86677062-86843889 bp, - strand  Genetic Position: Chr10, 43.14 cM
Alliance: Stab2tm1.1Cger page
Liver fibrosis in Stab1tm1.1Cger/Stab1tm1.1Cger Stab2tm1.1Cger/Stab2tm1.1Cger mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171818
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette with a 5' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Cre-mediated recombination removed the neo cassette and exon 1. Immunohistochemistry confirmed the absence of protein expression in the liver. (J:171818)
Generation of the Stab2tm1.1Cger allele
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stab2 Mutation:  138 strains or lines available
References
Original:  J:171818 Schledzewski K, et al., Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest. 2011 Feb 1;121(2):703-14
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory