Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Sean E Egan
• MGI ID: MGI:5000472
• Synonyms: R26-Pik3ca^H1047R
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170898
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pik3ca (MGI:1206581)

• Mutation details: The following sequences were inserted into intron 1: splice acceptor site, a STOP cassette (loxP site flanked neomycin resistance gene cassette), Pik3ca cDNA sequence where histidine codon 1047 (CAT) was changed to arginine (p.H1047R), and bovine GH poly(A) signal sequences. (J:170898)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 994 strains or lines available

References

• Original: J:170898 Adams JR, et al., Cooperation between Pik3ca and p53 Mutations in Mouse Mammary Tumor Formation. Cancer Res. 2011 Apr 1;71(7):2706-2717
• All: 46 reference(s)