Trp53^tm4Glo
Targeted Allele Detail

Summary

• Symbol: Trp53^tm4Glo
• Name: transformation related protein 53; targeted mutation 4, Guillermina Lozano
• MGI ID: MGI:5000493
• Synonyms: p53^neo
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm4Glo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171821
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site flanked neomycin resistance gene cassette was inserted into intron 4. Reduced protein expression was confirmed by western blot analysis on doxorubicin-treated mouse embryonic stem cells. This allele is hypomorphic. (J:171821)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm4Glo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:171821 Wang Y, et al., Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest. 2011 Mar 1;121(3):893-904
• All: 4 reference(s)