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Trp53tm4.1Glo
Targeted Allele Detail
Summary
Symbol: Trp53tm4.1Glo
Name: transformation related protein 53; targeted mutation 4.1, Guillermina Lozano
MGI ID: MGI:5000495
Synonyms: p53deltaneo
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm4.1Glo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171821
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Insertion
 
Mutation detailsCre-mediated recombination removed the loxP site flanked neomycin resistance gene cassette that was inserted into intron 4. Western blot analysis confirmed restored protein expression in doxorubicin-treated mouse embryonic fibroblasts. (J:171821)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Trp53tm4.1Glo
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  240 strains or lines available
References
Original:  J:171821 Wang Y, et al., Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest. 2011 Mar 1;121(3):893-904
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory