Cripto^tm2.2Mms
Targeted Allele Detail

Summary

• Symbol: Cripto^tm2.2Mms
• Name: cripto, EGF-CFC family member; targeted mutation 2.2, Michael M Shen
• MGI ID: MGI:5002491
• Synonyms: Cripto^2loxP, Cripto^flox
• Gene: Cripto Location: Chr9:110768676-110775226 bp, - strand Genetic Position: Chr9, 60.79 cM
• Alliance: Cripto^tm2.2Mms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104418
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP-flanked neomycin resistance (neo) cassette downstream of exon 5, and a single loxP site downstream of exon 2 of the teratocarcinoma-derived growth factor 1 (Tdgf1) gene. Cre-mediated recombination removed the neo cassette and left exons 3 through 5 floxed. (J:104418)

Expression

In Mice Carrying this Mutation:	49 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cripto Mutation: 55 strains or lines available

References

• Original: J:104418 Chu J, et al., Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis. Development. 2005 Dec;132(24):5539-51
• All: 6 reference(s)