Osr1^tm2.1Jian
Targeted Allele Detail

Summary

• Symbol: Osr1^tm2.1Jian
• Name: odd-skipped related transcription factor 1; targeted mutation 2.2, Rulang Jiang
• MGI ID: MGI:5003112
• Synonyms: Osr1^deltaE2
• Gene: Osr1 Location: Chr12:9624442-9631500 bp, + strand Genetic Position: Chr12, 4.05 cM
• Alliance: Osr1^tm2.1Jian page

Dilated epicardium, hemorrhaging, and edema in Osr1^tm2.1Jian/Osr1^tm2.1Jian embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171478
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Cre-mediated recombination removed exon 2. Homozygous mice recapitulate the phenotype of null mice. (J:171478)

Generation of the Osr1^tm2Jian, Osr1^tm2.1Jian, and Osr1^tm2.2Jian alleles

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Osr1 Mutation: 18 strains or lines available

References

• Original: J:171478 Gao Y, et al., The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol. 2011 Apr 1;352(1):83-91
• All: 4 reference(s)