Cul4a^tm1.2Pra
Targeted Allele Detail

Summary

• Symbol: Cul4a^tm1.2Pra
• Name: cullin 4A; targeted mutation 1.2, Pradip Raychaudhuri
• MGI ID: MGI:5003274
• Gene: Cul4a Location: Chr8:13155623-13197940 bp, + strand Genetic Position: Chr8, 5.73 cM
• Alliance: Cul4a^tm1.2Pra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171470
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 4 through 8. The absence of protein expression was confirmed by western blot analysis on testis, liver, heart, and brain extracts. (J:171470)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cul4a Mutation: 30 strains or lines available

References

• Original: J:171470 Kopanja D, et al., Cul4A is essential for spermatogenesis and male fertility. Dev Biol. 2011 Apr 15;352(2):278-87
• All: 2 reference(s)