Tg(PDGFB-APPSwDutLon)46Lpr
Transgene Detail

Summary

• Symbol: Tg(PDGFB-APPSwDutLon)46Lpr
• Name: transgene insertion 46, Laurent Pradier
• MGI ID: MGI:5003453
• Synonyms: PDGF-APP695SDL
• Transgene: Tg(PDGFB-APPSwDutLon)46Lpr Location: unknown
• Alliance: Tg(PDGFB-APPSwDutLon)46Lpr page

Transgene origin

• Strain of Origin: CBA x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-APPSwDutLon)46Lpr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  "The gene encodes for the Swedish, Dutch and London mutations."

• Mutation details: The human PDGF beta promoter drives expression of a human APP cDNA bearing 3 mutations Swedish (S: KM595/596NL), Dutch (D:E618Q), and London (L: V6421). This line has moderate overexpression of APP. (J:86694)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:86694 Blanchard V, et al., Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice. Exp Neurol. 2003 Nov;184(1):247-63
• All: 6 reference(s)