Tg(Hmgcr-PSEN1*M146L)#Lpr
Transgene Detail

Summary

• Symbol: Tg(Hmgcr-PSEN1*M146L)#Lpr
• Name: transgene insertion, Laurent Pradier
• MGI ID: MGI:5003458
• Synonyms: HMG-PS1M146L
• Transgene: Tg(Hmgcr-PSEN1*M146L)#Lpr Location: unknown
• Alliance: Tg(Hmgcr-PSEN1*M146L)#Lpr page

Transgene origin

• Strain of Origin: CBA x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Hmgcr-PSEN1*M146L)#Lpr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

• Mutation details: The murine Hmgcr promoter drives expression a human PSEN1 cDNA, which includes the intron between exons 4 and 5 and carries a methionine to leucine substitution at amino acid 146 (M146L). (J:86694)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:86694 Blanchard V, et al., Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice. Exp Neurol. 2003 Nov;184(1):247-63
• All: 23 reference(s)