Gt(ROSA)26Sor^{tm1(gp80,EGFP)Eces}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(gp80,EGFP)Eces}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ethel Cesarman
• MGI ID: MGI:5004724
• Synonyms: ROSA26.vFLIP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(gp80,EGFP)Eces} page

A representative tumor in the nose of a Gt(ROSA)26Sor^{tm1(gp80,EGFP)Eces}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺ mouse

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172031
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter) Mutation: Insertion Mutation details: A cassette containing (5' to 3') a splice acceptor, floxed neo/STOP cassette, the coding sequence for Kaposi sarcoma herpesvirus FLICE-inhibitory protein (vFLIP/gp80), and an FRT-flanked IRES-EGFP was inserted into the locus. Cre-mediated recombination is required to achieve expression of the viral protein. (J:172031)

Generation of the Gt(ROSA)26Sor^tm1(gp80,EGFP)Eces allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:172031 Ballon G, et al., Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice. J Clin Invest. 2011 Mar 1;121(3):1141-53
• All: 3 reference(s)