Rgs16^tm1Tmw
Targeted Allele Detail

Summary

• Symbol: Rgs16^tm1Tmw
• Name: regulator of G-protein signaling 16; targeted mutation 1, Thomas M Wilkie
• MGI ID: MGI:5004805
• Gene: Rgs16 Location: Chr1:153616099-153621212 bp, + strand Genetic Position: Chr1, 65.43 cM
• Alliance: Rgs16^tm1Tmw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172091
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5. The absence of protein expression was confirmed by western blot analysis. (J:172091)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rgs16 Mutation: 21 strains or lines available

Notes

ES cell line = MJ-1

References

• Original: J:172091 Pashkov V, et al., Regulator of G Protein Signaling (RGS16) Inhibits Hepatic Fatty Acid Oxidation in a Carbohydrate Response Element-binding Protein (ChREBP)-dependent Manner. J Biol Chem. 2011 Apr 29;286(17):15116-25
• All: 1 reference(s)