Kpna6^tm1Bdr
Targeted Allele Detail

Summary

• Symbol: Kpna6^tm1Bdr
• Name: karyopherin subunit alpha 6; targeted mutation 1, Michael Bader
• MGI ID: MGI:5004867
• Synonyms: alpha7^deltaIBB
• Gene: Kpna6 Location: Chr4:129537773-129566560 bp, - strand Genetic Position: Chr4, 63.28 cM, cytoband D2.3
• Alliance: Kpna6^tm1Bdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171441
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 2 was replaced with a floxed neo cassette via homologous recombination. An alternatively spliced mRNA encoding for a protein lacking the importin beta-binding domain is produced. Only a truncated non-functional protein is found in homozygous mutant testes and mRNA levels are strongly decreased as transcription from testis-specific exon 1A does not occur. (J:171441, J:311959)

Generation of the Kpna6^tm1Bdr allele

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kpna6 Mutation: 44 strains or lines available

References

• Original: J:171441 Rother F, et al., Importin alpha7 Is Essential for Zygotic Genome Activation and Early Mouse Development. PLoS One. 2011;6(3):e18310
• All: 7 reference(s)