Dppa3^tm1(cre)Peli
Targeted Allele Detail

Summary

• Symbol: Dppa3^tm1(cre)Peli
• Name: developmental pluripotency-associated 3; targeted mutation 1, Pentao Liu
• MGI ID: MGI:5004882
• Synonyms: Stella-cre
• Gene: Dppa3 Location: Chr6:122603383-122607230 bp, + strand Genetic Position: Chr6, 57.72 cM
• Alliance: Dppa3^tm1(cre)Peli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172071
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Dppa3^tm1(cre)Peli expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dppa3 (MGI:1920958)

• Mutation details: A targeting vector was generated by recombineering of a 129S5 BAC to contain an IRES-cre-Frt-Neo-Frt sequence. Homologous recombination in AB2.2 ES cells inserted the IRES-cre into the 3' untranslated region of Dppa3. Germline chimeras were bred to 129S5 females to generated heterozygotes. (J:175778)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dppa3 (mouse) Summary of all recombinase alleles driven by Dppa3. Alliance mouse Dppa3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dppa3 Mutation: 24 strains or lines available

References

• Original: J:172071 Vassiliou GS, et al., Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet. 2011 May;43(5):470-5
• All: 7 reference(s)