Ccn3^tm1Hko
Targeted Allele Detail

Summary

• Symbol: Ccn3^tm1Hko
• Name: cellular communication network factor 3; targeted mutation 1, Haruhiko Koseki
• MGI ID: MGI:5004902
• Synonyms: Ccn3 KO
• Gene: Ccn3 Location: Chr15:54609306-54617158 bp, + strand Genetic Position: Chr15, 21.49 cM
• Alliance: Ccn3^tm1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172144
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1, 2, and 3 were replaced with a neo cassette. The absence of protein expression was confirmed by immunohistochemistry on aorta. (J:172144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccn3 Mutation: 22 strains or lines available

References

• Original: J:172144 Shimoyama T, et al., CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):675-82
• All: 7 reference(s)