Aldh1a2^grim
Chemically induced Allele Detail

Summary

• Symbol: Aldh1a2^grim
• Name: aldehyde dehydrogenase family 1, subfamily A2; grimace
• MGI ID: MGI:5004939
• Synonyms: gri
• Gene: Aldh1a2 Location: Chr9:71123071-71203525 bp, + strand Genetic Position: Chr9, 39.85 cM
• Alliance: Aldh1a2^grim page

Contorted facial expression in E9.5-10.5 Aldh1a2^grim/Aldh1a2^grim embryos

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: 129S1/Sv or C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T-to-C base pair change in intron 4 of the gene disrupts splicing and leads to premature termination of translation of the encoded protein. Quantitative RT-PCR indicates expression in homozygotes is less than 1% that in wild-type embryos. (J:171522, J:185330)

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aldh1a2 Mutation: 38 strains or lines available

References

• Original: J:171522 Sandell LL, et al., A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development. Genesis. 2011 Apr;49(4):342-59
• All: 2 reference(s)