Notch1^sot
Chemically induced Allele Detail

Summary

• Symbol: Notch1^sot
• Name: notch 1; sottile tubo
• MGI ID: MGI:5004944
• Gene: Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
• Alliance: Notch1^sot page

Thin neural tube in E9.5-10.5 Notch1^sot/Notch1^sot embryos

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: 129S1/Sv or C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T-to-A base pair change creates an early stop codon and is predicted to truncate the normally 2531 amino acid protein to 84 amino acids. (J:171522)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch1 Mutation: 117 strains or lines available

References

• Original: J:171522 Sandell LL, et al., A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development. Genesis. 2011 Apr;49(4):342-59
• All: 1 reference(s)