Ptch1^wig
Chemically induced Allele Detail

Summary

• Symbol: Ptch1^wig
• Name: patched 1; wiggable
• MGI ID: MGI:5004953
• Gene: Ptch1 Location: Chr13:63656142-63721274 bp, - strand Genetic Position: Chr13, 32.8 cM
• Alliance: Ptch1^wig page

Excessive leaf-like laminae or folia in the brain of E9.5-10.5 Ptch1^wig/Ptch1^wig embryos resembling a wig

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: 129S1/Sv or C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• Mutation details: This phenotypic mutant was generated in an ENU mutagenesis screen for early craniofacial development phenotypes. Genome sequencing revealed a T to A nucleotide change in intron 15, which created a new splice acceptor site, resulting in a premature stop codon in exon 16 and generation of a truncated protein. (J:209623)

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptch1 Mutation: 115 strains or lines available

References

• Original: J:171522 Sandell LL, et al., A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development. Genesis. 2011 Apr;49(4):342-59
• All: 5 reference(s)