Wnt4^tm1.2Bhr
Targeted Allele Detail

Summary

• Symbol: Wnt4^tm1.2Bhr
• Name: wingless-type MMTV integration site family, member 4; targeted mutation 1.2, Richard R Behringer
• MGI ID: MGI:5006677
• Synonyms: Wnt4^del
• Gene: Wnt4 Location: Chr4:137004946-137026812 bp, + strand Genetic Position: Chr4, 69.8 cM
• Alliance: Wnt4^tm1.2Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171430
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP site and an FRT flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exon 2. (J:171430)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt4 Mutation: 21 strains or lines available

References

• Original: J:171430 Kobayashi A, et al., {beta}-Catenin is essential for Mullerian duct regression during male sexual differentiation. Development. 2011 May;138(10):1967-75
• All: 1 reference(s)